Archives of Clinical Neuropsychology · 2013 · 53 citations · 45 references
MedicinePsychiatryPsychologyFunctional DeclineNeuropsychiatryNeuropsychologyCognitive DeclineCognitive ImpairmentDepressive DisordersNeurocognitive DisordersNeurocognitive FunctionWorking Memory DeficitsCognitive Impairment In DepressionFunctional Impairment TrajectoriesNeurocognitive DeclineNeurocognitive DeficitsNeurocognitive FunctioningNeurocognitive ImpairmentNeurocognitive ProfileVerbal Memory
Treatment-resistant depression (TRD) refers to a condition where individuals with major depressive disorder have inadequate or no response to treatment. Although functional disability is a prominent and costly feature of treatment resistance, very little is known about the factors that contribute to and maintain functional impairment in TRD. This is the first study to report the neurocognitive profile of TRD and the relationships among neurocognition, symptoms, and functioning in this syndrome. Results indicated that patients with TRD (N = 33) exhibit mildly reduced performance across all neurocognitive domains with a superimposed moderate impairment in verbal working memory. Neurocognition was associated with functional competence (what one can do), whereas depressive symptoms were associated with functional performance (what one actually does). Understanding the psychological mechanisms related to functioning may help us move toward recovery in this chronically ill group.
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Aaron T. Beck, Norman Epstein, Gary Brown et al. · Journal of Consulting and Clinical Psychology · 1988 · 11.7K citations
The Epidemiology of Major Depressive Disorder
Ronald C. Kessler, Patricia A. Berglund, Olga Demler et al. · JAMA · 2003 · 8K citations