Defective Chemotactic Migration of Polymorphonuclear Leukocytes in Pelger-Huet Anomaly

Abstract

A decreased chemotactic migration of PMN in vivo and in vitro was observed in PMN from five individuals with P-H anomaly in a family. The decreased chemotactic migration was more pronounced when the PMN were made to migrate through a filter paper with small pore size. The decreased migration may be in part due to the mechanical hindrance of the large unsegmented nucleus to the migration of the cells.