Correlation of Histopathology, Islet Yield, and Islet Graft Function After Islet Autotransplantation in Chronic Pancreatitis

Abstract

More severe histopathologic changes were associated with a lower islet yield and lower likelihood of insulin independence. Total pancreatectomy and IAT should not be delayed in patients with painful chronic pancreatitis refractory to medical therapy; otherwise progressive damage to the pancreas may limit islet yield and increase the risk of diabetes.