Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

Eric R. Fearon, Drew M. Pardoll, Toshiuki Itaya et al. · Cell · 1990 · 922 citations

Life Sciences, Immunology, Oncology +17

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

Gary L. Clayman, Adel K. El‐Naggar, Scott M. Lippman et al. · Journal of Clinical Oncology · 1998 · 373 citations

Medicine, Molecular Medicine, Oncology +14

Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis.

Joseph Zabner, Bonnie W. Ramsey, David P. Meeker et al. · Journal of Clinical Investigation · 1996 · 264 citations · Full text

Medicine, Immunology, Molecular Biology +15

Immune Response to Recombinant Capsid Proteins of Adenovirus in Humans: Antifiber and Anti-Penton Base Antibodies Have a Synergistic Effect on Neutralizing Activity

Hanne Gahéry‐Ségard, Françoise Farace, Dominique Godfrin et al. · Journal of Virology · 1998 · 212 citations · Full text

Life Sciences, Immunology, Oncology +15

Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

Jonathan L. Bramson, Mary Hitt, Christina Addison et al. · Human Gene Therapy · 1996 · 191 citations · Full text

Life Sciences, Immunology, Oncology +17