Concepedia

A Scalable Synthesis of a Hydroxamic Acid LpxC Inhibitor

Zhongbo Fei, Weiyong Kong, Huaimin Wang, Jianbiao Peng, Yueyan Yin, Joginder S. Bajwa, Xinglong Jiang

Organic Process Research & Development · 2012 · 12 citations · 6 references

DOI

Concepts

Abstract

A short and scalable synthesis of chiral hydroxamic acid 1, a LpxC inhibitor, is described. This work discloses a novel diastereoselective addition of 2-nitropropane-generated lithium salt to tert -butanesulfinimine. Moreover, the impurity profiles of reactions giving oily products and practical means of purifying these products are discussed in detail.

References

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