Clinical Pharmacology of Carbenicillin Compared with Other Penicillins

Abstract

The high blood levels readily attainable with carbenicillin, especially when it is administered intravenously, are one of the main factors responsible for its efficacy in treatment of infections caused by organisms such as Pseudomonas that are relatively resistant in vitro. The purpose of this paper is to elucidate the mechanisms responsible for the high levels of the drug in the blood, to make comparisons with other penicillins, and to consider dosage regimens that are appropriate for various therapeutic purposes.