The Effect of Chronic Alveolar Hypoxia on Lung and Serum Angiotensin I Converting Enzyme Activity

Abstract

SummaryMice exposed to chronic alveolar hypoxia showed elevations of serum and lung angiotensin I converting enzyme activity during the second week of exposure. The increment of activity of the lung and serum converting enzyme was of the same order of magnitude and occurred at approximately the same time. An increase in renal renin granules was closely correlated with both lung and serum converting enzyme activity.