Recent Development of Benzotriazole-based Medicinal Drugs

Abstract

The inhibition of kinases is one of the most important pathways to treat cancers attributing to the significant roles of kinases in cell multiplication The special structure of benzotriazole derivatives could readily bind with different kinases via multiple non-covalent forces such as hydrogen bonds, coordination, ion-dipole, cation-, - stacking, hydrophobic effect and van der Waals force, thus effectively inhibiting the activity of various kinases including protein kinases CK2 and CHK1, histone deacetylases and focal adhesion kinase and so on.