Publication | Open Access
Stability, Specific Binding Activity, and Plasma Concentration in Mice of an Oligodeoxynucleotide Modified at 5'-Terminal with Poly (ethylene glycol).
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1995
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Molecular PharmacologyEthylene GlycolNucleic Acid ChemistryBioorganic ChemistryBiochemistryHexylamine LinkerSpecific Binding ActivityNatural SciencesPolymer-drug ConjugateNucleic Acid BiochemistryGlycobiologyOligodeoxynucleotide ModifiedOligonucleotideGene DeliveryAntisense TherapyMedicineVivo RetentionBiomolecular Engineering
Oligodeoxynucleotide (ODN) composed of 15 nucleotides was modified at 5'-terminal phosphate with hexylamine linker and chemically activated poly(ethylene glycol). This derivative showed improved characteristics in terms of enzymatic stability, binding activity, and in vivo retention in mouse. The data are discussed in comparison with those of corresponding unmodified and phosphorothioate ODNs.