Effect of salicylate and disodium ethylenediaminetetraacetic acid on the rat intestinal absorption of cefmetazole.

Abstract

The enhancement by disodium ethylenediaminetetraacetic acid (EDTA) of cefmetazole absorption from rat jejunum and colon was dependent on the pH of the administered solution. The higher the pH of the administered solution, the greater the effect of EDTA. However, the enhancement by salicylate of the cefmetazole absorption was dependent on salicylate absorption rather than on the pH of the administered solution. The effectiveness of EDTA was similar at the colon and at the jejunum, while salicylate showed a significantly greater effect at the colon than at the jejunum.