The Mechanism of Satiety: Effect of Glucagon on Gastric Hunger Contractions in Man.

Abstract

SummaryAdministration of glucagon intravenously to 7 normal subjects resulted in prompt abolition of gastric hunger contractions on each of 16 occasions. This was associated with decrease in the experience of hunger and coincided with a rise in blood glucose levels and an increased peripheral capillary-venous glucose difference. Fall in blood glucose levels with decreasing capillary-venous differences was associated with a return of hunger contractions and intensification of the experience of hunger in 14 of the 16 occasions. Such a pattern may be a component of the normal satiety mechanism.