Punched out multiple myeloma lytic lesions in the skull

Abstract

Multiple myeloma (MM) is a neoplastic proliferation of a clonal population of plasma cells, which produces monoclonal protein (immunoglobulin G [IgG], IgA, and light chain protein κ or λ are the most common). 1 The plasma cells neoplasia affects the bones—including the skull—leading to extensive skeletal destruction due to osteolytic lesions and osteopenia, with consequent pathologic fractures. 2 Other cardinal features of MM are bone pain, fatigue, weight loss, anemia, hypercalcemia, hypergammaglobulinemia with a monoclonal protein in serum or in the urine, renal insufficiency, and secondary infections. 1