Antimicrobial Action of Pyocyanine, Hemipyocyanine, Pyocyanase, and Tyrothricin

Abstract

SummaryThe inhibition of growth of bacteria, yeasts and pathogenic fungi by natural and synthetic pyocyanine, synthetic hemipyocyanine, and natural pyocyanase and tyrothricin has been investigated. Natural and synthetic pyocyanine have equal activities which surpass those of pyocyanase. Tyrothricin is particularly inhibitory for Gram positive bacteria, especially streptococci. The considerable fungistatic potency of tyrothricin and hemipyocyanine suggests that these substances may be of value in the treatment of fungus infections.