Publication | Closed Access
Atmospheric Pressure Ionization (API) Mass Spectrometry. Solvent-Mediated Ionization of Samples Introduced in Solution and in a Liquid Chromatograph Effluent Stream
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1974
Year
Clinical Mass SpectrometryBiological Mass SpectrometryIon Mobility SpectrometryAtmospheric Pressure IonizationChemistryEnvironmental ChemistryAnalytical InstrumentationGas ChromatographySamples IntroducedEnvironmental Analytical ChemistryAnalytical ChemistryLiquid ChromatographyChromatographyApi SourceBiochemistryMetabolomicsComputational Mass SpectrometryChromatographic AnalysisEnvironmental EngineeringNatural SciencesMass SpectrometryProtein Mass SpectrometryNative Mass SpectrometryMedicineDrug Analysis
Atmospheric pressure ionization (API) mass spectrometry is a novel form of mass spectrometry in which ions are generated in a reaction chamber external to the low pressure region of a quadrupole mass analyzer. Samples may be introduced in solvent-free fashion (by vaporization in a stream of preheated carrier gas, or in the effluent stream from a gas chromatograph) or with solvents (by injection of solutions, or in the effluent stream from a liquid chromatograph). Solvent-mediated ionization reactions leading to positive ions were studied. A liquid chromatograph-mass spectrometer-computer (LC-MS-COM) analytical system was constructed; the entire effluent stream from the chromatograph was vaporized through the API source.