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Interferon Production by Human Leucocytes in vitro. Reduced Levels In Lymphatic Leukemia.
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1966
Year
Human LeucocytesLymphocyte DevelopmentImmunologyBlood CellPathologyImmune SystemImmunotherapyInterferon ResponseHematological MalignancyDepressed Interferon LevelHematologyInterferon ProductionAutoimmune DiseaseAutoimmunityCell BiologyMalignant Blood DisorderSendai-sindbis SystemAdult T-cell Leukemia-lymphomaMedicineLymphatic Leukemia
In vitro production of interferon by human normal and leukemic leucocytes, employing the Sendai-Sindbis system, has been compared. The interferon response of leucocytes derived from 13 treated cases of acute and chronic lymphatic leukemia, have been found to be markedly lower than that of normal controls. Likewise, one untreated case of acute lymphatic leukemia, also showed a depressed interferon level.