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A Novel Drug and Gene Co-Delivery System Based on Poly(<I>ε</I>-caprolactone)-Poly(ethylene glycol)-Poly(<I>ε</I>-caprolactone) Grafted Polyethyleneimine Micelle
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2010
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Ethylene GlycolEngineeringSmart PolymerResponsive PolymersGene DeliveryBiomedical EngineeringCationic Pcec-g-pei MicellesNanomedicineNovel DnaDrug Delivery SystemNovel DrugPolymer ChemistryMolecular EngineeringDelivery SystemGene TherapiesPolymer-drug ConjugatePolymer SciencePcec-g-pei MicellesDrug Delivery SystemsMedicinePolyethyleneimine Micelle
In this paper, we prepared a novel cationic self-assembled micelle from poly(epsilon-caprolactone)-poly(ethyl glycol)-poly(epsilon-caprolactone) grafted polyethyleneimine (PCEC-g-PEI). The PCEC-g-PEI micelles, formed by self-assembly method, had mean particle size of ca. 82 nm and zeta potential of +22.5 mV at 37 degrees C, and could efficiently transfer pGFP into HEK293 cells in vitro. Meanwhile, as a model hydrophobic chemotherapeutic drug, honokiol was loaded into PCEC-g-PEI micelles by direct dissolution method assisted by ultrasonication. The honokiol loaded cationic PCEC-g-PEI micelles could effectively adsorb DNA onto its surface, while it could release honokiol in an extended period in vitro. This study demonstrated a novel DNA and hydrophobic chemotherapeutic drug co-delivery system.