A Comparison of the Effect of Vitamin B₁₂with That of Liver Extract in the Treatment of Pernicious Anemia during Relapse and for Maintenance

Abstract

SINCE the isolation of vitamin B12 from liver and its extracts by Rickes and his associates1 and by Smith,2 sufficient evidence of its effectiveness for the control of pernicious anemia has been presented so that a detailed discussion of this question need not be included here. The early studies of West,3 Spies,4 West and Reisner5 and others have demonstrated that vitamin B12 when administered parenterally will initiate a remission of the anemia and control the other manifestations of the disease as liver does when ingested or given parenterally in extract form. Few direct comparisons of these effects and . . .