Global analysis of age-structured within-host virus model

Abstract

A mathematical model of a within-host viral infection with explicit age-since-infection structure for infected cells is presented. A global analysis of the model is conducted. It is shown that when the basic reproductive number falls below unity, the infection dies out. On the contrary, when the basic reproductive number exceeds unity, there exists a unique positive equilibrium that attracts all positive solutions of the model. The global stability analysis combines the existence of a compact global attractor and a Lyapunov function.