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Long-Term Maintenance of Normal Human Skin on Congenitally Athymic (Nude) Mice
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1973
Year
Tissue EngineeringImmunologyTissue TransplantationCongenitally AthymicDermatologyEmbryologyRegenerative MedicineLong-term MaintenanceNonhuman SubjectsExperimental DermatologyCell TransplantationKnockout MouseSkin DevelopmentXenotransplantationNormal Human SkinCutaneous BiologySkin SubstituteDevelopmental BiologyPhysiologyLifetime Full ThicknessWound HealingMedicineDermal Structure
SummaryCongenitally athymic (nude) mice have been shown to accept for their lifetime full thickness, normal human skin grafts without immunosuppressive therapy. The biological and medical significance of the long-term maintenance of human tissues in nonhuman subjects is discussed.