Erythropoietic Activity of Tissue Homogenates.

Abstract

Homogenates of rat liver, kidney, brain, spleen and muscle prepared in modified Tyrode's solution and injected into the rat are capable of stimulating erythropoiesis as measured by Fe59 incorporation into red cells and reticulocyte counts. The activity of the homogenates does not appear to be a nonspecific effect. Certain points of similarity are noted between the homogenates and plasma erythropoietin.