Iron Status, Anemia, and Plasma Erythropoietin Levels in Acute and Chronic Mouse Models of Colitis

Abstract

The measurements of iron, whether in acute (dextran sodium sulfate) or chronic (T-cell transfer) models of colitis, were generally consistent with iron-deficient anemia, with large increases in erythropoietin indicative of tissue hypoxia. These changes in animal models of colitis are similar to those found in human IBD.