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Biosynthesis of Lysophosphatidic Acid from ATP and 1-Monoolein by Subcellular Particles of Intestinal Mucosa
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1969
Year
EngineeringDigestive TractBiosynthesisFatty AcidsSubcellular ParticlesLysophosphatidic AcidNatural Product BiosynthesisMetabolismBiochemistryIntestinal MucosaLipidsBiomolecular EngineeringCellular EnzymologyLipid MetabolismPhysiologyFat AbsorptionLipid ChemistryMedicineLipid Synthesis
Evidence is presented that incubation of monoolein with ATP, fatty acids, and other appropriate additions in the presence of subcellular fractions from intestinal mucosal cells results in the formation of lysophosphatidic acid (LPA). These results indicate that LPA is an intermediate in the formation of phosphoglycerides in the intestinal mucosa during fat absorption.