The Usefulness of Toluidine Red Unheated Serum Test in the Diagnosis of HIV-Negative Neurosyphilis

Abstract

In Brief We retrospectively analyzed the Venereal Disease Research Laboratory test, Treponema pallidum particle agglutination test, and toluidine red unheated serum test (TRUST) in 41 cases of HIV-negative neurosyphilis and 34 non-neurologic syphilitic patient and found that serum-TRUST titers could be the indication of lumbar puncture in syphilitic patients and a reactive cerebrospinal fluid-TRUST is considered diagnostic to neurosyphilis. In a study of clients in a teaching hospital in Guangzhou, China, we found that the TRUST (toluidine red unheated serum test) could be a useful alternative test for diagnosis of neurosyphilis.