Copper-Catalyzed β-Trifluoromethylation of Conjugated Hydrazones

Abstract

The Cu-catalyzed direct β-trifluoromethylation of α,β-unsaturated aldehyde N,N-dibenzylhydrazones with Togni hypervalent iodine reagent is described. The reaction yields stereodefined CF3-alkenyl derivatives under mild conditions and is proposed to proceed via a radical process.