Interaction of tri-O-methyl-.BETA.-cyclodextrin with drugs. II. Enhanced bioavailability of ketoprofen in rats when administered with tri-O-methyl-.BETA.-cyclodextrin.

Abstract

The interaction of ketoprofen with tri-O-methyl-β-cyclodextrin (methyl-β-CD) was investigated in vitro and in vivo. The phase solubility diagram revealed a linear relationship (AL type), and the solubility of ketoprofen in 0.1 M methyl-β-CD aqueous solution was 20 times that in pure water. The bioavailability of ketoprofen following oral administration with methyl-β-CD to rats was 3.7 times that of ketoprofen alone.