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Description of a novel approach for intraperitoneal drug delivery and the related device
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2011
Year
LaparoscopyEngineeringGastroenterologyNovel ApproachVisceral SurgerySurgeryBiomedical EngineeringSite-specific DeliveryNanomedicineDrug Delivery SystemSuch Therapeutic PneumoperitoneumIntraperitoneal Drug DeliveryTargeted Drug DeliveryPharmacologyDelivery SystemNano-drug DeliveryDrug DistributionMedicinePoor PenetrationDrug DiscoveryAnesthesiologyRelated Device
Aims: Two significant limitations of intraperitoneal drug therapy are (1) limited drug distribution and (2) poor penetration into peritoneal nodules. A possible solution is the application of the so-called ‘therapeutic pneumoperitoneum’, taking advantage of the gaseous nature and of the pressure of capnoperitoneum during laparoscopy. Objective was to develop a device able to apply such therapeutic pneumoperitoneum.