Synthesis of Optically Active <i>N</i>‐Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy–Thiourea Catalyst

Abstract

Thiourea makes peptides: Asymmetric Petasis reactions with vinylboronates and α-iminoamides are effectively catalyzed by the novel hydroxy–thiourea catalyst 1 (up to 86 % yield, 93 % ee; see scheme). This reaction can be applied not only to the synthesis of the unnatural amino acid monomers but also to peptide oligomers. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.