Amelioration of Diabetes Mellitus by an Insulinoma

Abstract

' I 'HE occurrence of a functioning islet-cell tumor -1- of the pancreas in a patient with diabetes mellitus is an exceedingly rare phenomenon. We have recently studied a patient who demonstrated a gradual amelioration of diabetes over a period of nine years that finally culminated in frank episodes of spontaneous hypoglycemia. Laparotomy revealed a large islet-cell tumor of the pancreas. Excision of the neoplasm afforded complete relief of the hypoglycemia and re-emergence of the diabetic state. The preoperative diagnosis of an insulinoma was complicated by the coexistence of diffuse liver disease.Case ReportN.J., a 67-year-old Hebrew man, entered . . .