Lung Damage in Mice Following Intraperitoneal Injection of Butylated Hydroxytoluene

Abstract

SummaryButylated hydroxytoluene was administered intraperitoneally to two strains of mice in the dose range 0.004-2.5 g/kg. Histological examination of the lung tissue revealed thickened interalveolar septa, congestion and a general pattern of tissue disorganization at doses of 0.25 g/kg and above. The observed effects are apparently reversible and have a threshold in the vicinity of 0.04 g/kg.