Effect of Ascorbic Acid on Diabetogenic Action of Alloxan

Abstract

Administration of ascorbic acid to rats which are given low doses of alloxan increases the diabetogenic action of the alloxan. To obtain this effect the alloxan must be given within a minute after the administration of the ascorbic acid. d-Isoascorbic acid? on the other hand, does not produce the potentiation of the alloxan diabetes.