HERG and KvLQT1/IsK, the Cardiac K+ Channels Involved in Long QT Syndromes, Are Targets for Calcium Channel Blockers

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction

New England Journal of Medicine · 1989 · 3.3K citations

Medicine, Cardiology, Pharmacology +14

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

Michael C. Sanguinetti, Mark Curran, Anruo Zou et al. · Nature · 1996 · 1.8K citations

Natural Sciences, Biochemistry, Molecular Biology +12

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

Jacques Barhanin, Florian Lesage, Eric Guillemare et al. · Nature · 1996 · 1.6K citations

Natural Sciences, Molecular Biology, Physiology +12