Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK 506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771. - Concepedia

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Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK 506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771.

DOI Full Paper Access

24

Citations

8

References

1992

Year

Tom S. Chen, Byron H. Arison, Linda S. Wicker, Edward Inamine, Richard L. Monaghan

The Journal of Antibiotics

Abstract

The immunosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

References

	Year	Citations

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