Production of Penicillinase by Bacteria

Abstract

A simple test for the qualitative and quantitative determination of penicillinase produced by bacteria is described. Bacteria capable of producing penicillinase are widely distributed in nature; such organisms vary considerably as to the amount of penicillinase they produce. The possible significance of penicillinase and penicillinase-producing bacteria in relation to penicillin therapy is discussed.