Synthesis of a Liphagal–Frondosin C Hybrid and Speculation on the Biosynthesis of the Frondosins

Abstract

A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Paternò-Büchi reaction/fragmentation pathway.