Proteins of Heart in Experimental Cardiac Hypertrophy in the Rat.

Abstract

SummaryProtein fractions of hearts from rats in which cardiac hypertrophy was produced by exposure to elevated environmental temperature and reduced atmospheric pressure were studied. Increases occurred in all fractions but in a disproportionate manner. Largest increases were observed in the following fractions: (1) I5, due in part to an apparent increase in myoglobin, (2) in the contractile Fraction II β, due in part to appearance of a component not normally demonstrated, and (3) in the mitochondrial fraction. It is suggested that these changes represent an adaptation to work demands placed upon the heart under experimental conditions.