Nonsteroidal anti‐inflammatory drugs enhance IgE‐mediated activation of human basophils in patients with food anaphylaxis dependent on and independent of nonsteroidal anti‐inflammatory drugs

Abstract

This study indicates that subjects with food-induced anaphylaxis differ from FDNIA subjects in the higher reactivity and sensitivity of their basophils to allergen challenge. We have shown a direct effect of NSAIDs on basophils using a human model of FDNIA. Our results also suggest that selective COX2 inhibitors might be a safe alternative. BA test may be a useful tool in the study of the pathogenic mechanism of the cofactor phenomenon.