Concepedia

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

Silvio E. Inzucchi, David Maggs, Geralyn Spollett, Stephanie L. Page, Frances Rife, Veronika Walton, Gerald I. Shulman

New England Journal of Medicine · 1998 · 795 citations · 22 references

DOIFull text

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Abstract

Metformin and troglitazone have equal and additive beneficial effects on glycemic control in patients with type 2 diabetes. Metformin acts primarily by decreasing endogenous glucose production, and troglitazone by increasing the rate of peripheral glucose disposal.

References

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