Studies on Synthetic Nucleotides. I. A Convenient Synthesis of Ribonucleotides.

Abstract

A convenient synthetic procedure of pyrimidine and purine nucleotides was described. The fusion of phosphorylated acylhalogenoses with trimethylsilylpyrimidines or-purines and then removal of the protecting groups gave several nucleotides in good yields. The structural confirmation of the nucleotides thus obtained was achieved by chromatographic and spectral analyses, as well as comparison with the authentic samples prepared by the known methods.