PubMed · 1997 · 16 citations · 0 references
Life SciencesBiochemistryPharmacologyCellular MetabolismHepatotoxicologyMetabolismChemical-induced HepatotoxicityHepatotoxicity MechanismsLipid MetabolismLipid PeroxidationMolecular Mechanisms Of ToxicityOxidative Stress In HepatotoxicityAntioxidant Protection Against HepatotoxicityCarbon Tetrachloride HepatotoxicityCarbon Tetrachloride ToxicityLipid Peroxidation In HepatotoxicityLipid Peroxidation MarkersLiver Injury MechanismsOxidative Stress In HepatocytesOxidative Stress In Liver Injury
It has been found out that the carbon tetrachloride (CCl4)-induced increase of serum glutamic-pyruvic transaminase (ALT) and elevation of MDA in liver of mice are significantly lowered by Phyllanthus urinaria in vivo, and the coincubation of isolated rat hepatocytes with Phyllanthus urinaria in vitro significantly inhibits CCl4-induced decrease of mobility of membrane of liver cells and increase of intracellular free Ca2+ ([Ca2+]i) concentrations of liver cells. These results suggest that the anti-lipid peroxidation effect and protective action of membrane of Phyllanthus urinaria may be related to its protective action against CCl4-induced liver injuries.