Prognostic Significance of TEL/AML1 Fusion Transcript in Childhood B-Precursor Acute Lymphoblastic Leukemia

Abstract

This study confirmed that TEL/AML1 gene fusion is the most common genetic event in pediatric ALL in Japan and is restricted to CD10-positive B-precursor ALL. Moreover, it was associated with an improved survival rate among patients treated with intensive therapy. Therefore, these data suggest that the patients with TEL/AML1 may not necessarily be candidates for less aggressive treatment.