Comparison of High and Low Dosage Levels of¹³¹I in the Treatment of Thyrotoxicosis

Abstract

THE appearance of permanent hypothyroidism several years after treatment of thyrotoxicosis with radioactive iodine (131I) was pointed out in the review of Chapman and Maloof1 in 1955. Its steadily increasing occurrence during the passage of time was reported in 1961 by Beling and Einhorn.2 The data of Dunn and Chapman3 show that radioactive iodine hypothyroidism occurs in 25 per cent of patients two years after 131I, the rate steadily increasing to 40 per cent after ten years.3 More recently, Nofal, Beierwaltes and Patno4 reported permanent hypothyroidism in 45 per cent after two years, the figure reaching about 70 per . . .