Publication | Open Access
Effect of vitamin B6 deficiency on collagen metabolism in rats.
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1976
Year
NutritionCollagen MetabolismVitamin B6 DeficiencyOxidative StressMolecular NutritionPublic HealthMineral MetabolismAnimal PhysiologyNutrient PhysiologyBiochemistrySkin CollagenVitamin B ComplexEndocrinologyPharmacologyVitamin NutritionPhysiologyNutritional ScienceMetabolismMedicineVb6 DeficiencyExtracellular Matrix
The effects of VB6 deficiency on collagen metabolism were studied using young and adult rats. It was observed in VB6 deficient rats, that both the amount of urinary hydroxyproline and salt soluble fraction of skin collagen decreased. Furthermore, decrease of the alpha-component and increase of the beta-component were also found in the soluble collagen. However, the activity of plasma amine oxidase was lower and the aldehyde content in the acid soluble collagen were also lower than the control group. These changes were revealed more clearly in young growing rats than in adult rats. Based on these results, it may be that VB6 participates in the allysine (alpha-amino-adipic-delta-semialdehyde) formation which is considered as the first step of collagen maturation and also in the synthesis of protocollagen peptide chains.