Absorption, distribution and excretion of triphenyltin acetate and stannic chloride in the guinea pig.

Abstract

Percutaneous absorption of 113Sn-triphenyltin acetate (113Sn-TPTA) was studied after the chemical was applied to guinea pig skin. Of the dose 3.04% and 7.97% were absorbed through the skin and 16.3% and 12.4% were found in the applied area 1 and 2 days after application, respectively.After a subcutaneous (sc) injection of 113Sn-TPTA, radioactivity was found in the liver, kidney and brain in large amounts, though absorption from the injected site proceeded slowly. The body retention of radioactivity showed a biological half time of 9.4 days, and about 83% of the dose was excreted in the feces within 20 days of dosage.The radioactive concentration was greatest in the bone and kidney after an sc injection of 113SnCl4. No transfer to the brain was detected. Absorption from the injected site and excretion, whose main route was urinary, were greatly delayed. The biological half time was estimated to be 26.5 days.The intact compound, 113Sn-diphenyltin and 113Sn-monophenyltin were identified as the chemical forms of radiotin excreted in the feces after an sc injection of 113Sn-TPTA.