Concepedia

Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.

Andrei V. Blokhin, Hye‐Dong Yoo, Robin S. Geralds, Dale G. Nagle, William H. Gerwick, Ernest Hamel

Molecular Pharmacology · 1995 · 86 citations · 0 references

Concepts

Life SciencesBiochemistryMedicinal ChemistryBiophysical ChemistryEnzymologyProtein-protein InteractionsMarine Natural ProductsMarine PharmacologyMicrotubule Assembly InhibitionMicrotubule-associated ProteinsMicrotubule-targeting AgentsAntimitotic ActivityAntimitotic DrugsColchicine Site BindingDrug Binding Sites On TubulinInhibition Of Tubulin AssemblyNatural Product Microtubule InhibitorsTubulin Binding InhibitionTubulin Binding Sites