CARCINOGENICITY STUDY OF TRIS (2-CHLOROETHYL) PHOSPHATE IN ddY MICE

Abstract

Groups of 50 male and 50 female ddY mice were fed commercial diet containing 0, 0.012, 0.06, 0.3, and 1.5% tris (2-chloroethyl) phosphate (TCEP) for 18 months. In both sexes fed 1.5% TCEP, body weight gain was apparently suppressed and mortality rates were clearly higher compared to other groups. After histopathological examination, the incidences of renal cell carcinomas and adenomas were significantly increased in males fed 1.5% TCEP. The incidences of hepatocellular adenomas were significantly high in the 0.3 and 1.5% groups of males. In females, significant increases were found in the incidences of papillomas and squamous cell carcinomas (combined) of the 1.5% group, and in those of leukemias of the 0.3 and 1.5% groups. Under the conditions of this study, orally administered TCEP was carcinogenic to ddY mice, causing significantly high incidences of tumors in the kidney and liver of male mice and in the forestomach and hematopoietic organ of female mice.