Rate of Glycogenesis in Liver of Depancreatized Rat after Parenteral Administration of Glucose and Fructose.

Abstract

1. Following intraperitoneal injection, fructose formed liver glycogen more rapidly, and to a greater extent, than glucose in depancreatized rats. 2. When injected intraperitoneally, glucose formed liver glycogen as rapidly in depancreatized rats as in normal rats. 3. Absence of the pancreas from the otherwise intact rat showed no apparent effect upon activity of any of the enzymes involved in formation of glycogen from fructose or glucose in the liver. 4. The data obtained suggest that the metabolic processes in the liver involved in formation of glycogen from fructose or glucose are not directly influenced by insulin.