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Production of Dietary Vit. K Deficiency in the Rat.
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1959
Year
Animal PhysiologyNutritionNutrient PhysiologyPhysiologyPathogenesisDietary IntakePathologyClinical NutritionSevere VitEndocrinologyPublic HealthMetabolismMedicinePotassium HomeostasisDaily MenadioneExperimental NutritionK Deficiency
A diet is described which produces a severe Vit. K deficiency in the rat in less than 10 days. The deficiency was manifested by prolonged plasma prothrombin times and hemorrhages. Daily menadione supplementation protected rats from the deficiency. Coprophagy appeared to be the means by which Vit. K synthesized by the intestinal microflora becomes available to the rat.