Retention of Human Properties by a Xenografted Human Colonic Tumor, GW-77, Propagated in Unconditioned Hamsters

Abstract

The unlimited serial propagation of a human colonic tumor, GW-77, in unconditioned, adult golden hamsters raises the question of its still possessing “human” properties. Both the direct fluorescent antibody test and its LDH isoenzyme-mobility pattern reveal the human species-specific character of GW-77. The retainment of its original species-identity is consistent with its relatively less malignant, only locally expansive, growth-behavior in various sites of the hamster.