3,4-Dimethoxybenzyl group: A new protecting group for the guanosine residue during oligonucleotide synthesis.

Abstract

The protection of the O6-amide group of deoxyguanosine with the 3, 4-methoxybenzyl group is described. This protecting group could be introduced effectively and was readily removed with DDQ. This was used to demonstrate the synthesis of the oligodeoxyribonucleotide.