Fluoren-9-ylmethyloxycarbonyl (Fmoc) amino acid chloride as an efficient reagent for anchoring Fmoc amino acid to 4-alkoxybenzyl alcohol resin.

Abstract

Esterification of Fmoc amino acids to 4-alkoxybenzyl alcohol polystyrene through acid chlorides was achieved in high yield with practically no racemization. This reaction is especially effective for the rapid anchoring of amino acids which have bulky side chains.